| Acronym | Definition |
|---|
| LSD | d-Lysergic Acid Diethylamide (psychedelic drug) |
| LSD | Least Significant Difference (statistics) |
| LSD | Limited Slip Differential (drive axels on cross country vehicles) |
| LSD | Limited Slip Differential |
| LSD | Lucy in the Sky with Diamonds (Beatles song) |
| LSD | Lake Shore Drive |
| LSD | Love Sensuality Devotion (Enigma album) |
| LSD | Long Slow Distance (fitness training) |
| LSD | Low Sulfur Diesel (fuel) |
| LSD | Law Student Division (American Bar Association) |
| LSD | Landing Ship, Dock (aka Dock Landing Ship) |
| LSD | Lietuvos Standartizacijos Departamentas (Lithuanian Standards Board) |
| LSD | Last Stage of Delirium (Polish web security group) |
| LSD | Least Significant Digit |
| LSD | Fisher's Least Significant Difference (statistics; analysis) |
| LSD | Low Self Discharge (battery chemistry) |
| LSD | Love's Secret Domain (album by band Coil) |
| LSD | Lysosomal Storage Disease |
| LSD | Local Spin Density |
| LSD | Lakeshore Drive |
| LSD | Louisiana School for the Deaf |
| LSD | Lumpy Skin Disease |
| LSD | Legal Surveys Division (Canada) |
| LSD | Latin Square Design (statistics) |
| LSD | Lean Software Development (efficiency in software development) |
| LSD | Life Sciences Division |
| LSD | Pounds, Shillings and Pence (UK slang for currency) |
| LSD | Lyserg Saeure Diaethylamid (German) |
| LSD | Life Science Dictionary |
| LSD | Liquid Sound Design |
| LSD | Large-Screen Display |
| LSD | Lansing School District (Michigan) |
| LSD | Low Speed Data (videoconferencing data channel) |
| LSD | Life, Sex, and Death (band) |
| LSD | Lead Singer Disease (when a singer leaves a band to go solo due to ego) |
| LSD | Light Shaping Diffuser |
| LSD | Labor Saving Device |
| LSD | Love Spirals Downward (band) |
| LSD | Lamborghini Style Doors (automobile design) |
| LSD | Librae Solidi Denarii (Pounds Shillings Pence) UK & Ireland |
| LSD | Laboratory for Simulation Development |
| LSD | Love Sex & Dating |
| LSD | Lysine-Specific Demethylase (biology) |
| LSD | Lysergic Acid Diethlamide |
| LSD | Legislative Services Division (Montana) |
| LSD | Location Service Daemon (Java EJB) |
| LSD | Long Slow Death |
| LSD | Low Side Driver (electrical engineering) |
| LSD | Little Snazzy Drummer |
| LSD | Laser Supported Detonation (waves) |
| LSD | Life Saving Device (song) |
| LSD | Lashed Secured Dunnaged (shipping) |
| LSD | Little Spike Dudley (pro wrestler) |
| LSD | Linacre School of Defence |
| LSD | Lower Slower Delaware |
| LSD | Lead System Designer |
| LSD | Light Sensitive Diode |
| LSD | Legal Services Developer |
| LSD | Legal Self Defense |
| LSD | Lexington School for the Deaf (Jackson Heights, New York) |
| LSD | List Sphere Decoding |
| LSD | Lorenzo Saint Dubois (movie,The Producers) |
| LSD | Lone Star Draft (beer) |
| LSD | Loud Style Design |
| LSD | Lethbridge School District (California) |
| LSD | Low Starch Diet |
| LSD | Legal Survey Description |
| LSD | Logarithmic Standard Deviation |
| LSD | Learn, Start, Do (Grand Theft Auto) |
| LSD | Lighting Sensitive Displays |
| LSD | Littérature Sémo-Définitionnelle (Italian) |
| LSD | Laboratory for System Dynamics and Signal Processing |
| LSD | Least Separation Distance |
| LSD | La Sourie Deglinguee (French rock band) |
| LSD | Line Signal Detect (equivalent to carrier detect on a DSU) |
| LSD | List Server for Domino (email list program; Bright Ideas Software) |
| LSD | Little Silly Dish (small consumer grade satellite receivers) |
| LSD | Logistic Support Detachment |
| LSD | Lowland Search Dogs (UK) |
| LSD | Los Santos Delivery (gaming, GTA:San Andreas) |
| LSD | Large Scope Dissemination |
| LSD | Liberal Studies Division |
| LSD | Liberty Sanitation Department (Grand Theft Auto reference) |
| LSD | Louisiana Super Dome |
| LSD | Logic and Semantics for Dummies |
| LSD | Local Slope Data |
| LSD | Logistics Support Directorate |
| LSD | Land Surface, Depth From |
| LSD | Local Service Desk |
| LSD | Lucifer's Stained Dress (song) |
| LSD | Large Size Dry |
| LSD | Lulie St Dash |
| LSD | Laser Spot Detector |
| LSD | Loop Signaling Device |
| LSD | Lost Souls of Darkness (game) |
| LSD | Lifestyle and Social Discourse |
| LSD | Love Stops Depression |
| LSD | Langley Swim and Dive |
| LSD | Live Status Display |
| LSD | Lashing, Stowage und Dunnage (German) |
| LSD | Lymphatic System Disorder |
| LSD | Liquid Scintillator/Scintillation Detector |
| LSD | Lowest Significant Dose |
| LSD | Lunar Surface Drill |
| LSD | Logistics Support Data/Document |
| LSD | Lucid Sun Divine (Mary Pranksters song) |
| LSD | Large-Scale Distributed (computer systems) |
| LSD | Layton Service Desk (Tampa, FL) |
| LSD | Limit States Design (engineering) |
| LSD | Leafy Sea Dragon (marine fish) |
| LSD | Life Span Development (psychology) |
| LSD | League for Spiritual Discovery (est. 1966) |
| LSD | Law School Discussion (forum) |
| LSD | Land Systems Division (various locations) |