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1999) found that there did not appear to be a threshold dose for estradiol-induced sex reversal of turtle embryos, the lowest dose tested (40 pg/g, ppt) showing 14% sex reversal in the turtle embryos. Viral load reductions were about one log at the lowest dose tested, 1. In the Company's previously reported single-dose Phase I study of TRIOLEX for the treatment of metabolic disorders, the compound was shown to be orally bioavailable in humans, with significant drug concentrations detected in the blood at the lowest dose tested, and all doses of TRIOLEX appeared to be safe and well tolerated in healthy volunteers with no reported drug related adverse side effects to date. |
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