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The primary endpoint of the study was the percentage change in lumbar spine bone mineral density. Long-term Phase II studies show that lasofoxifene has an improved profile in bone parameters, such as markers of bone resorption and one- and two-year lumbar spine bone mineral density with significant improvement over the current leading SERM, In clinical trials, Fosamax achieved a mean increase of up to 10 percent in lumbar spine bone mineral density (the primary endpoint) vs. |
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