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MAGUKMembrane-Associated Guanylate Kinase
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The sequences in the C-terminal region of epidermal growth factor protein-tyrosine kinase receptors that are recognized directly by WW domain-containing proteins such as YAP, other receptor families such as MAGUK, and indirectly by tumor suppressor proteins such as P73, highlight the broad and important role of the WW domain family and AxCell's proprietary technology in discovering new pathways associated with cancer and other diseases.
Similarly, the Q460R substitution falls at the boundary of an SH3 binding domain (42), which may be important for recruiting the scaffolding protein MAGuK and phosphatidylinositol-4 kinase involved in subunit assembly of proteins involved in exocytosis and membrane trafficking (45, 46).