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MAGUKMembrane-Associated Guanylate Kinase
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Abbreviations: AMPAR, a-amino-3-hydroxy-5-methy1-4-isoxazolepro-pionic acid receptor; LTD, long-term depression; LIP, long-term potentiation; MAGUK, membrane-associated guanylate kinase protein; NMDAR.
The C-terminus of Occludin is capable of interacting directly with actin filaments, PKC-, the tyrosine kinase Yes, and PI-3 kinase, as well as with the MAGUK proteins ZO-1, ZO-2, and ZO-3.
Similarly, the Q460R substitution falls at the boundary of an SH3 binding domain (42), which may be important for recruiting the scaffolding protein MAGuK and phosphatidylinositol-4 kinase involved in subunit assembly of proteins involved in exocytosis and membrane trafficking (45, 46).