MALDI-TOFMatrix Assisted Laser Desorption Ionization - Time of Flight
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The subject of the tender is: It is a complete system with mass spectrometric ionization laser sample for the presence of matrix (Matrix Assisted Laser Desorption / Ionization) and two analyzers flight time (Time of Flight), abbreviated MALDI-TOF / TOF.
MALDI-TOF is primarily used to identify colonies growing on agar media.
The approved MALDI-TOF mass spec platform might be referred to as "smart automation," It doesn't simply automate a chore or process that people would otherwise have to do.
Bruker Daltonics has diverse technology platforms that integrate automated sample preparation and clean-up, advanced front-end AnchorChip[TM] MALDI targets and API source technology with cutting-edge proprietary MALDI-TOF, MALDI-TOF/TOF, ESI-TOF, ESI-Q-q-TOF, ion trap and FTMS mass analyzers, as well as analysis and bioinformatics software.
MALDI-TOF MS is amenable to tissue imaging applications because it is a straightforward process.
Lastly, it was demonstrated that the power spectrum of the noise in a typical MALDI-TOF mass spectrum cannot be predicted solely from the experimental conditions; and therefore, blind application of smoothing and/or filtering algorithms may unintentionally remove information from the data which is detrimental to quantitation.
Theo Luider, Head of the Laboratories of Neuro-Oncology, Department of Neurology, Erasmus University of Rotterdam, pointed out: "We have been working with MALDI-TOF mass spectrometry for many years originally in the field of clinical proteomics, but more recently the increased usage of the MALDI-TOF approach for microbial identification also became an area of interest for us.
The application of MALDI-TOF MS to the diagnosis of microbial infections has been touted as a revolution in clinical microbiology.
The technology is not cleared yet by the FDA for clinical use, but our research indicates that MALDI-TOF MS holds great potential to improve patient care.
Bruker Daltonics also introduced tandem TOF/TOF versions of both its ultraflex III and ultraflex III MALDI-TOF systems.
Peaks from MALDI-TOF raw data (which exhibit the proteins extant in a biosample) must be brought into registration to correct for random fluctuations before they can be used to classify samples (for example, as diseased or nondiseased).