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Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes. He added that "Kinexus is routinely tracking over 1000 phosphorylation sites with its proteomics screening services, and it has already identified the JNK and p38 MAPK protein kinases as drug targets using the Kinetworks(TM) method. Both R5 gp120 and X4 gp120 activate the MAP kinases p38 and c-Jun amino terminal kinase/stress-activated protein kinase (JNK/SAPK), though it is unclear whether a third member of the MAPK family, extracellular regulated kinase (ERK 1/2), is activated. |
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