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MAdCAM-1Mucosal Addressin Cell Adhesion Molecule 1
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MAdCAM-1 is mainly expressed on gut endothelial cells and plays a critical role in the homing of T-lymphocytes to gut lymph tissue.
LeukoSite researchers have shown, in a non-human primate model of IBD, that blocking the binding of the alpha-4 beta-7 integrin, a homing receptor on lymphocytes, to MAdCAM-1, an adhesion receptor on the cells of blood vessels lining the intestine, can prevent lymphocyte infiltration and lessen the symptoms of IBD.