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MAdCAM-1Mucosal Addressin Cell Adhesion Molecule 1
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In mesenteric lymph node HEVs, MAdCAM-1, a sialomucin bearing two immunoglobulin-like domains, (15) serves as a vascular addressin, and [alpha]4[beta]7 integrin serves as the cognate lymphocyte receptor that mediates rolling and adhesion, (16) as described below.
1993) MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1.
Vedolizumab specifically binds to the alpha4beta7 integrin and blocks its interaction with MAdCAM-1, therefore inhibiting the white blood cells from entering the inflamed gut tissue, thus decreasing inflammation.