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MCL1Myeloid Cell Leukemia 1
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The protein is elevated in a variety of cancers, and a number of MCL1 inhibitors are in the cancer drug development pipeline worldwide.
7) In childhood acute lymphoblastic leukemia (ALL), resistance to glucocorticoids (which induce leukemia cell death or apoptosis) and high levels of expression of the anti-apoptotic MCL1, are predictive of a poor prognosis.
Jude Department of Cell and Molecular Biology, came evidence that switching off the MCL1 gene in bone marrow led to the death of granulocytes, but not monocytes, via apoptosis.
In this study, researchers identified the protein MCL1 as the partner in crime of BCR-ABL.