Increased levels of pro-inflammatory cytokines such as IL6 and MCP1
reduce insulin secretion in human and mouse islets (Sauter et al.
In mice with chronic alcohol treatment, genes related with M1 phenotype such as TNF-[alpha], MCP1
, and IL-1[beta] and genes associated with M2 macrophages such as Arg1, Mrc1, and IL-10 as well as the population of CD206(+)CD163(+) M2 macrophages were improved in the liver.
Abbreviations EC epicatechin ECG epicatechin gallate ECC epigallocatechin EGCG epigallocatechin-3-gallate eNOS endothelial nitric oxide synthase HO-1 heme oxygenase-1 ICAM1 intercellular adhesion molecule-1 JNK c-Jun N-terminal kinase HUVEC human umbilical vein endothelial cells 3-MA 3-Methyladenine MCP1
monocyte chemoattractant protein-1 NO nitric oxide PAI-1 plasminogen activator inhibitor-1 ROS reactive oxygen species TNF-[alpha] tumor necrosis factor alpha VCAM1 vascular cell adhesion molecule-1 VEGF vascular endothelial growth factor vWF von Willebrand factor
FGF21 RBP4 IL-6 MCP1
TNF-[alpha] Correlation coefficient 0.
mRNA level of TNF[alpha] (tumor necrosis factor), IL1[beta] (interleukin 1 beta), MIP1[alpha] (macrophage inflammatory protein-1 alpha), MCP1
(CD46), MAP1lc3 (microtubule-associated protein 1 light chain 3), VPS11 (vacuolar protein sorting-associated protein 11), or [beta] actin was detected by reverse transcription and real-time PCR.
In mice, the MCP1
produced by Kupffer cells has been reported to exert monocyte-specific chemotactic activity and to be involved in inflammation within the liver .
0 Fluorescent signal on adipokine microsphere, % (a) IL8 IP10 Lept MCP1
MCSF Adipokine recombinant protein Adiponectin 0.
2001), IL-8, MIP-1[alpha], MCP1
(Pfeilschifter et al.
We observed differential stimulation of RANTES and MCP1
in the cervical and pulmonary cell lines.
Jones, "Curcumin supplementation lowers TNF-[alpha], IL-6, IL-8, and MCP1
secretion in high glucose-treated cultured monocytes and blood levels of TNF-[alpha], IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats," Antioxidants and Redox Signaling, vol.
and IL8 mRNAs were increased by AIR ligands in both types of cells (Figure 2A, B).