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When in doubt of this diagnosis, nuclear immunoreactivity of MDM2 and cyclin-dependent kinase 4 (CDK4) are confirmatory, which correspond to amplification of these genes.
PTEN protects P53 from MDM2 and sensitizes cancer cells to chemotherapy.
Prior to examining whether Hbo1 ubiquitinates ER[alpha] LBD, to confirm that our assay system for ubiquitination is appropriate, we checked whether Mdm2 ubiquitinates p53 in vitro41) by our assay.
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein binase B/Akt-dependent phosphorylation.
The over-expression of p53, p21 and MDM2 provided supportive experimental evidences that EAD induced apoptosis via p53-dependent pathway (Fig.
Moreover, Nrf2 is directly involved in the basal expression of the p53 inhibitor Mdm2, through the binding to the ARE sequence located in the first intron of this gene, and inhibits cell death .
Kaneko, "Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma," Cancer Genetics and Cytogenetics, vol.
Evaluation of p53, PCNA, Ki-67, MDM2 and AgNOR in oral peripheral and central giant cell lesions.
In fact, histological differentiation between fibrous dysplasia and low-grade central osteosarcoma can be difficult and may only be possible in the presence of cortical break-through or tumor expression of MDM2 or CDK4.
We used the following antibodies: for histone acetylation analysis: anti-acetyl histone H3-Lys 9 (H3K9), antiacetyl histone H4-Lys 12, and anti-acetyl histone H4-Lys 16 (all from Millipore); for intracellular protein analysis: anti-PARP, MDM2 (mouse double minute 2 homolog), p53 phosphorylated serine 15, p53, BID, caspase-3, and [beta]-actin (all from Cell Signaling Technology).
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.
intracerebroventricular; PVN, paraventricular nuclei; CRH, cor ticotropin releasing hormone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; IL-4, interleukin-4; VHL, Von Hippel Lindau; hypoxia-inducible factor 1-a; FOXM1, forkhead box protein M1; mdm2, mouse double minute 2 homolog.
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- MDM 2 Binding Protein
- MDM Application Test Environment
- Mdm38 homolog