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Several molecular mechanisms that contribute to drug resistance have been identified, including increased mRNA levels for two types of efflux pump genes: the ATP binding cassette transporter CDRs (CDR1 and CDR2) and the major facilitator MDR1 (Mah, 2012; White et al.
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-[kappa]B signaling inhibition.
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
It has been shown to increase cytochrome P450 (CYP450) (Braun 2005), in particular CYP3A4 (Durr 2000), as well as increasing Pglycoprotein/ MDR1 expression with a 3.
MDR1 encodes P-glycoprotein, a key protein involved in drug transport that is known to modulate drug disposition.
To investigate whether silent mutations play a role, Gottesman and his colleagues worked with different varieties of the gene called MDR1, which makes P-glycoprotein.
Other reports have also implicated a number of other SNPs in genes of the folate metabolism pathway, including MDR1, ABCB1, RFC, ATIC, TS enhance region (TSER), adenosine monophosphate demaniase (AMPDA) and inosine triphosphat pyrophosphate (ITPA) (12-16).
11) Incel (biricodar dicitrate, II Small molecule blocker of VX-710) multidrug-resistant pumps MDR1 gene and multidrug resistance- associated protein.
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more MDR1 genes.
P-glycoprotein, which is a membrane protein that functions as an exporter of xenobiotics from cells, is a product of the MDR1 gene.
those tumor cells that survive in the presence of Taxol), the researchers identified seven peptides that allowed for increased Taxol resistance, one of which consistently had the highest survival rate and was linked to upregulation of the gene ABCB1 (also known as MDR1 for multiple drug resistance).
ACTIVATION OF MDR1 GENES BY MUTANT P53 REQUIRES INTERACTION WITH A CELLULAR PROTEIN.
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- MDR system
- MDR tuberculosis
- mdr-1 gene