Of the 132 samples extracted, one sample returned no lignocaine or MEGX
despite samples either side returning significant levels of both lignocaine and MEGX
MEGX hydrochloride and lidocaine hydrochloride were kind gifts from Astra (Stockholm, Sweden).
Integration of peak areas, calculation of peak-area ratios, calculation of the calibration line, and calculation of the MEGX concentrations were performed with the PE Sciex TurboQuan[TM] (Ver.
To assess the possible interference of this drug with the MEGX test, we measured MEGX concentrations in three healthy volunteers before and 2 weeks after administration of calcitriol at daily doses similar to those taken by uremic patients.
Blood samples for MEGX determination were collected in heparin-containing plastic tubes before and 10, 15, 30, 45, and 60 min after lidocaine administration.
An automated fluorescence polarization immunoassay (FPIA; Abbot Diagnostics Division, Chicago, IL) is widely available for MEGX
determination in serum.
Determination of lidocaine and MEGX
simultaneously may be useful in evaluation of liver impairment.
1) Nonstandard abbreviations: PK, pharmacokinetics; PD, pharmacodynamics; DUS, digoxin-like immunoreactive substances; MEGX
, monoethylglycinexylidide; and IV, intravenous.
All hepatitis patients in the study had a percutaneous liver biopsy within 1 week of MEGX
Some studies suggest that MEGX
formation has better prognostic value than the Child-Pugh classification in patients with end-stage liver disease, including selection of appropriate transplant candidates [177,178].
Donor hyaluronic acid and MEGX
levels do not accurately predict posttransplant liver function.
Chicago, IL) of MEGX
in serum is almost universally available and widely used.