2011) proposed that MEHP might disturb neurodevelopment by suppressing cell proliferation and promoting cell differentiation towards a cholinergic phenotype that may relate to hyperactivity based on iw vitro findings in neuronotypic PC12 cells.
The limits of detection (LOD) for MMP, MEP, MBP, MBzP, MEHP, MEHHP, and MEOHP were 3.
We summed molar concentrations of MEHP
, MEHHP, MECPP, and MEOHP to represent total metabolites of di(2-ethylhexyl) phthalate (DEHP).
The proportions of metabolite observations below the LOD were 5% for all metabolites other than MEHP
(21% < LOD) and MiBP (18% < LOD).
Phthalate Parent phthalate diesters group LMW DEP Diethyl phthalate MEP DnBP Di-n-butyl phthalate MnBP DiBP Diisobutyl phthalate MiBP BBzP Butylbenzyl phthalate MBzP HMW DEHP Di(2-ethylhexyl) phthalate MEHP
MEHHP MEOHP MECPP DOP Dioctyl phthalate MOP MCPPS DiNP Diisononyl phthalate MiNP MHiNP MOiNP MCiOP Phthalate Measurable urinary metabolites LOD group (ng/mL) LMW DEP Monoethyl phthalate 0.
Until now, no one had done such a study on the effects of exposure to doses of MEHP
in adult mice while they were still in utero.
Pubertal jinekomasti hastalarinda plazma DEHP duzeyleri 4,67[+ or -]1,58 ppm ve plazma MEHP
duzeyleri 3,19[+ or -]1,41 ppm olarak tayin edilmis ve bu degerlerin kontrol grubuna kiyasla (DEHP: 3,1[+ or -]0,90 ppm ve MEHP
: 1,39[+ or -]0,36 ppm) onemli olcude (p<0,05) yuksek oldugu bulunmustur (14).
In an upcoming Environmental Health Perspectives, the researchers report that the 65 newborns in the study who had detectable blood concentrations of MEHP
were born after an average of 38.
, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) concentrations were converted from micrograms per liter to micromoles per liter using molecular weights (278, 294, 292, and 308 g/mol) and summed to create [summation]DEHP.
exposure in vitro causes apoptotic germ cell loss in human fetal testis explants (Lambrot et al.
The urinary levels of MEHP
and 5oxo-MEH were highly correlated (Pearson's r > 0.
For example, the metabolite MEHP
exhibited much stronger PPAR[gamma] binding potency than its parent compound, DEHP (Feige et al.