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MERIT-HF

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AcronymDefinition
MERIT-HFMetoprolol CR/XL (Controlled Release/Extended Release) Randomized Intervention Trial in Chronic Heart Failure


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For example, the dose of metoprolol tartrate [Lopressor] used in COMET (50 mg twice daily) is not equivalent to the target dose of metoprolol succinate [Toprol XL] used in the MERIT-HF study (200 mg once daily) that demonstrated the effectiveness of metoprolol succinate in HF.
Results of the analysis, which compared all-cause mortality in participants in the COPERNICUS, MERIT-HF, CIBIS-II and BEST trials, suggest that differences in survival associated with beta-blocker treatment observed in clinical trials may be significantly influenced by inclusion of varying geographic populations (U.
The MERIT-HF study, published in the Lancet in 1999, showed that percentages of death from SCD ranged from 33 to 64 percent in heart failure patients with Class II to Class IV functional status, a measure of the progression of their disease state.
 
 
 
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