30[degrees] inclined screen test: Swiss albino mice (male) after 15 mm of injection of either propylene glycol (5 ml/kg), Diazepam (10 mg/kg) or MERN (100, 200 and 300 mg/kg) were left on the screen for at least 4 h to observe whether the paralysant effect was severe enough to cause the mice to slide off the screen (Randall, 1960).
with MERN at different doses (200 and 400 mg/kg) while the third group and fourth group of animals received propylene glycol (5 ml/kg) and Diazepam (10 mg/kg) respectively.
Experiments were conducted in groups of six animals at 30, 60, 90 and 120 mm after the intraperitoneal injection of either MERN (200 and 300 mg/kg), propylene glycol (5 ml/kg) or Diazepam (10 mg/kg).
It was noted that MERN affected the spontaneous activity, sound, pain and touch responses at the dose of 200 mg/kg and above produced moderate
In the traction test, MERN in doses of 200 mg/kg and above produced significant failure in traction.
On the basis of the results obtained from the Y-maze test after treatment with MERN in different doses (200 and 400 mg/kg), it was observed that there was a significant decrease in the exploratory behaviour of rats when compared with the respective controls (Table 4).