The respective databases are based on the international standards developed by the MGED Society (Brazma et al.
FDA), NCT (NIEHS), Minister of Health Labour and Welfare-National Institute of Health Sciences Project in Japan, Netherlands Genomics Initiative, and EMBL-EBI, where informatic scientists are working with experimental practictioners and the MGED Society to ensure that transcriptomic experiments can be mapped on to regulatory toxicology studies].
Since its inception in 1999, the MGED
Society has been working with the broader scientific community to establish standards for the exchange and annotation of microarray data.
uk/ miamexpress/) is an online annotation and submission tool presented in the form of a MIAME-based questionnaire, where MGED Ontology is used to structure inputs and provide controlled vocabularies for entry.
Tox-MIAMExpress uses MGED Ontology concepts that point to established controlled vocabularies for toxicological end points: the International Union of Pure and Applied Chemistry (http://www.
has expert working groups on a) experimental description and data representation standards; b) microarray data extensible markup language (XML) exchange format (CEBS will use XML for data exchange); c) ontology (Karp 2000) for sample description (CEBS will follow the gene ontologies of the Gene Ontology (GO) Consortium at http:// www.