5] Nonstandard abbreviations: FDA, US Food and Drug Administration; NCI, National Cancer Institute; ICTRP, International Clinical Trials Registry Platform; ICMJE, International Committee of Medical Journal Editors; HUGO, Human Gene Organisation; TKI, tyrosine kinase inhibitor; CTBS, Clinical Trials Biomarkers Standards; FGED, Functional Genomics Data Society; MGED
, Microarray Gene Expression Data Society; MIAME, minimum information needed to describe a microarray experiment; REMARK, Reporting recommendations for tumor MARKer; BRISQ, biospecimen reporting for improved study quality; API, application programming interface; HGNC, HUGO Gene Nomenclature Committee; HGVS, Human Genome Variation Society; regex, regular expression; RESTful, REpresentational State Transfer.
The respective databases are based on the international standards developed by the MGED Society (Brazma et al.
FDA), NCT (NIEHS), Minister of Health Labour and Welfare-National Institute of Health Sciences Project in Japan, Netherlands Genomics Initiative, and EMBL-EBI, where informatic scientists are working with experimental practictioners and the MGED Society to ensure that transcriptomic experiments can be mapped on to regulatory toxicology studies].
uk/ miamexpress/) is an online annotation and submission tool presented in the form of a MIAME-based questionnaire, where MGED Ontology is used to structure inputs and provide controlled vocabularies for entry.
Tox-MIAMExpress uses MGED Ontology concepts that point to established controlled vocabularies for toxicological end points: the International Union of Pure and Applied Chemistry (http://www.