4) In 2010 the other centres were co-opted into assessing their own patient records, largely retrospectively, and documenting age at onset, presenting MGFA grade, maximum severity, duration of follow-up, outcome on treatment and specifically paresis of EOMs and eyelids/ptosis.
The MGFA and EOM grades were considered ordinal variables.
Overall, the median MGFA grade at disease presentation was mild (grade 2; IQR 2-3), deteriorating to a maximum grade of 3 or moderate disease severity (IQR 2-5) and improving to a final grade 1 (IQR 0-2), with 45% (60/133) in functional remission (minimal manifestation status).
3-44 years), shows that the thymectomy group had more severe disease (54% MGFA grade 4 or 5) compared with the non-thymectomy group (19% MGFA grade 4 or 5).
The MGFA grades at presentation and frequency of AChR-positive generalised MG among this cohort were similar to other juvenile cohorts.