The researchers said that while they expect similar MHCII expression to occur in overweight male humans and female mice, further studies are needed to establish this.
This dialogue between adipocytes and T cells appears to initiate the inflammatory response to high fat diet -- Hsueh and her group found that overfed mice lacking MHCII experienced less inflammation.
The researchers found high expression of most MHCII complex and MHCII antigen processing genes.
Contrary to conventional wisdom, the research team found that the peptide presented in the register that binds most weakly to the MHCII molecule stimulated four different T cells associated with diabetes.
All three have been peptides that are weakly bound to the MHCII molecule," said Kappler.
4] Nonstandard abbreviations: TNF, tumor necrosis factor; NK, natural killer; RT-PCR, reverse-transcription PCR; SOFA, Sequential Organ Failure Assessment; SAPS II, Simplified Acute Physiology Score II; MHCII
, major histocompatibility complex class II; Cq, quantification cycle; IL-1/[beta], interleukin-1/[beta].