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FDG PET/CT is recommended in select cases for restaging if the tumour is not MIBG avid or it has a low affinity for MIBG.
MIBG scintigraphy has an excellent sensitivity and specificity in localizing pheochromocytomas.
MIBG has a high sensitivity and specificity in detecting phaeochromocytomas (Fig.
On this basis, I-131 MIBG is sensitive and specific for detecting localised and metastatic neuroblastoma, phaeochromocytoma, paraganglioma and medullary thyroid carcinoma.
For MRI-detected abnormalities that require further investigation, CT scanning or MIBG might be performed.
Suggestive features: REM sleep behavior disorder, severe antipsychotic sensitivity, decreased tracer uptake in striatum on SPECT dopamine transporter imaging or on myocardial scintigraphy with MIBG
The MIBG scan (Figure 1) shows an increased uptake in a small region adjacent to the junction of the abdominal aorta and the inferior mesenteric artery.
We monitored the patient closely using regular imaging to identify any early recurrence of tumor using a whole-body MIBG diagnostic scan and a whole-body indium-1 1 1 octreotide scan.
His own studies suggest that MIBG cardiac uptake may parallel the progression of Parkinson's disease.
Together with Don Weiland, PhD, and Ray Counsell, PhD, they developed MIBG for imaging and treatment of adrenomedullary tumors.
The patient was discharged 7 days after the operation and a follow-up examination after 24 months, including whole-body CT and MIBG (iodine-131-meta-iodobenzylguanidine), showed no evidence of recurrence or metastatic finding.