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MIP2Macrophage Inflammatory Protein 2
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Data for the inflammatory response derived from the concentrations of IL-1[beta] and MIP2 in BALF are presented in Figures 6 and 7, respectively.
In Figures 6B and 7B, the low-dose response data for IL-1[beta] and MIP2 are also presented on logarithmic dose scales, which is to illustrate that sufficiently detailed measurements at low doses provide a better means of identifying the zero-dose response (or offset) than using a rather limited number of sham or control experiments.
To characterize the degree of inflammatory changes in the lung at a molecular level, we analyzed the amount of various proinflammatory cytokines released into the alveolar space: IL1-[beta] and TNF-[alpha], two cytokines commonly produced by activated monocytes, and MIP2 and KC, two potent neutrophil attractants that represent the murine functional homologs to human IL-8.