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MKLP1Mitotic Kinesin-Like Protein 1
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Live cell imaging and immunolabeling for microtubules and the centralspindlin constituent and kinesin-related protein, MKLP1, demonstrated that furrowing in ammonia-activated eggs was associated with aligned arrays of centralspindlin-linked, opposed bundles of antiparallel microtubules.
These complexes are 1) centralspindlin, consisting of the mitotic kinesin MKLP1 (also known as kinesin 6) and the Rho family GAP CYK-4 (also known as MgcRacGAP); and 2) the chromosomal passenger complex (CPC), consisting of the Aurora B kinase and three additional proteins involved in its localization and activation: INCENP, Survivin, and Borealin.
Centralspindlin, a complex of MKLP1 and CYK-4, is thought to help organize post-anaphase microtubules into the central spindle, and also to provide the scaffold for recruitment of the RhoGEF Ect2, which mediates the equatorial activation of RhoA and assembly of the contractile ring (Jantsch-Plunger et al.