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MMAE

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AcronymDefinition
MMAEMechanical, Materials and Aerospace Engineering
MMAEMonomethyl Auristatin E
MMAEMultiple Model Adaptive Estimation (Bayesian technique using Kalman filters)
MMAEMultiple Model Adaptive Estimator
MMAEMethod of Matched Asymptotic Expansions


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? References in periodicals archive
In an oral presentation, preclinical data show that SGN-35 effectively targets CD30 and delivers MMAE to tumor cells resulting in potent cell-killing.
The ADC is designed to be stable in the bloodstream, but to release MMAE upon internalization into CD30-expressing tumor cells, resulting in a targeted cell-killing effect.
This ADC technology employs synthetic, highly potent drugs, such as MMAE, that can be attached to antibodies through proprietary linker systems.
 
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