MOGCTMalignant Ovarian Germ Cell Tumors
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OCT3/4, also known as POU5F1, is possibly one of the most useful antibodies in the diagnosis of MOGCTs.
However, since it is a pluripotency marker, it can show positivity in EC, YS(PE)T, and primitive areas of immature teratoma; consequently, it represents a good, broad marker for MOGCTs.
This is especially applicable to ovarian MOGCTs for which mixed forms of malignant germ cell tumors are rare and overlapping among various neoplastic phenotypes is minimal.