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MPTP |
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23-25) For example, Woodlee and Schallert (23) found the onset of abnormal movements to be prevented or delayed when parkinsonian rats exposed to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) were trained in an enriched environment. At least one environmental contaminant, an industrial chemical called MPTP, has been directly linked to the onset of Parkinson's, and researchers have found that some herbicides, pesticides, and heavy metals may cause symptoms similar to those of the disease. 2003) suggested that a number of different dithiocarbamates potentiate the toxicity of both MPTP and paraquat in mouse models of parkinsonism. |
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