| Acronym | Definition |
|---|
| MSF | Motorcycle Safety Foundation |
| MSF | Microsoft Solutions Framework |
| MSF | Médicos Sin Fronteras (Spanish: Doctors Without Borders; humanitarian group) |
| MSF | Master of Science in Finance (academic degree) |
| MSF | Multiservice Switching Forum (MCI, Cisco, Bellcore, etc) |
| MSF | Multi-Stage Flash |
| MSF | Thousand Square Feet |
| MSF | Michigan Strategic Fund |
| MSF | Manufacturing Science and Finance Union (UK) |
| MSF | Mission Support Flight |
| MSF | Manned Space Flight |
| MSF | Mysinglefriend (dating website) |
| MSF | Mobile Strike Force (US Army Special Forces) |
| MSF | Monthly Service Fee |
| MSF | Megakaryocyte-Stimulating Factor |
| MSF | Merchant Service Fee |
| MSF | Magnetic Silencing Facility |
| MSF | Mind Science Foundation (San Antonio, TX) |
| MSF | Mass Storage Facility |
| MSF | Muhammad Subuh Foundation (Rotterdam, The Netherlands) |
| MSF | Minnesota Senior Federation |
| MSF | Mines Shopping Fair |
| MSF | Monthly Subscription Fee |
| MSF | MLL Septin-Like Fusion Gene |
| MSF | Module Support Frame (engineering) |
| MSF | Managing the Search Function |
| MSF | Matched Spatial Filter |
| MSF | Maximum Service Flow (highway capacity, civil engineering) |
| MSF | Mobile Striking Force |
| MSF | Most Significant First (byte order) |
| MSF | Master of Science in Forestry |
| MSF | Major Street-Basketball Foundation (Australia) |
| MSF | Military Space Forces (VKS, Russia) |
| MSF | Mass Storage Function |
| MSF | Mobile Screening Force (US Transportation Security Administration) |
| MSF | Moebius Syndrome Foundation (Pilot Grove, Missouri) |
| MSF | multiplex signal format (US DoD) |
| MSF | Monroe State Forest (Massachusetts) |
| MSF | Moroccan Social Forum |
| MSF | Multi-Stream Forwarding |
| MSF | Marine Services Fee (Canada) |
| MSF | Male Seeking Female |
| MSF | Mobility Support Forces |
| MSF | Mobile Security Forces |
| MSF | Main Support Frame |
| MSF | Military Sub-Function |
| MSF | Mission Support Force |
| MSF | Message Switching Function |
| MSF | Mail Services Framework |
| MSF | Mean of Square Fitting Faults |
| MSF | Management System Factor |
| MSF | Managed Spam Filtering (Navisite) |
| MSF | Market Street Fund |
| MSF | Microcomputer Support Facility |
| MSF | Minimum Stream Flow (water) |
| MSF | mIRC Script Francophone |
| MSF | Michigan Sugar Festival (Sebewaing, Michigan) |
| MSF | Missionary Supplementary Funds (LDS Church) |
| MSF | Modernize and Sustain Forces |
| MSF | Meconium Stain Fluid (medical) |
| MSF | Congregation of Missionaries of the Holy Family (religious order) |
| MSF | Missile Security Forces |
| MSF | Mail Service Facility |
| MSF | Malaysian Scholars Foundation |
| MSF | Mid-Stream Fee |
| MSF | Medecins sans Frontiéres (French: Doctors without Borders) |
| MSF | Matthew Shepard Foundation (Denver, CO) |
| MSF | Mercy and Sharing Foundation (Colorado) |
| MSF | Milan Simecka Foundation (Slovakia) |
| MSF | Multi-Strategy Fund (various companies) |
| MSF | Medium Sized Firm |
| MSF | Morning Star Fishermen (Dade City, FL) |
| MSF | Missouri State Fair |
| MSF | Multiple Sclerosis Foundation |
| MSF | Multi-Sensor Fusion |