| Acronym | Definition |
|---|
| MAD | Mutually Assured Destruction |
| MAD | Mean Absolute Deviation |
| MAD | Madonna |
| MAD | Make A Difference |
| MAD | Moroccan Dirham (ISO currency code) |
| MAD | Mpeg Audio Decoder |
| MAD | Mind Altering Drug(s) |
| MAD | Militärischer Abschirmdienst (Military Secret Service, Germany) |
| MAD | Mobile Armor Division |
| MAD | Museum of Arts & Design (formerly American Craft Museum) |
| MAD | Multiple Ascending Dose (clinical trials) |
| MAD | Median Absolute Deviation |
| MAD | Mean And Dirty (Inspector Gadget) |
| MAD | Multiwavelength Anomalous Diffraction |
| MAD | Maintien a Domicile (French: Housekeeper) |
| MAD | Market Abuse Directive (UK) |
| MAD | Motivated and Determined |
| MAD | Mean Absolute Difference |
| MAD | Mosquito Abatement District |
| MAD | Myoadenylate Deaminase Deficiency |
| MAD | Master Agility Dog (dog agility title) |
| MAD | Motorists Against Detection (UK anti speed camera group) |
| MAD | Major Affective Disorder |
| MAD | Marine Aviation Detachment |
| MAd | Mouse Adenovirus |
| MAD | Multiple Acyl-CoA Dehydrogenase |
| MAD | Madrid, Spain - Barajas (Airport Code) |
| MAD | Moisture and Density |
| MAD | Michigan Algorithmic Decoder |
| MAD | Message Address Directory |
| MAD | Magara Arastirma Dernegi (cave research society, Turkey) |
| MAD | Middle-Aged Dating |
| MAD | military air distress (US DoD) |
| MAD | Magnetic Audio Device |
| MAD | Memory Address Driver (BIOS) |
| MAD | Montana Association of the Deaf |
| MAD | Multiple Access Device |
| MAD | My Adorable Darling |
| MAD | MAC-Address Descriptor (Cisco) |
| MAD | Magazine des Arts et du Divertissement (French: Arts and Entertainment Magazine; Belgium) |
| MAD | Mass Acceleration Diagram |
| MAD | Mean Administrative Delay (ITU-T) |
| MAD | Mean Aerodynamic Diameter |
| MAD | Maladjusted, Antisocial, and Darn Mean (Tom of Thumb) |
| MAD | Maintenance Assembly-Disassembly |
| MAD | Mini Attack Drone |
| MAD | Mis-Aligned Die (coinage) |
| MAD | Maximum Allowable Delay |
| MAD | Motorcycle Adventure Destinations |
| MAD | Master Account Domain |
| MAD | Mixed Anxiety and Depression disorder |
| MAD | Medical Anchor Desk |
| MAD | Multiaperture Device |
| MAD | Managing Archaeological Data |
| MAD | Mission Area Deficiency |
| MAD | Marina Academic Decathlon (Huntington Beach, California) |
| MAD | Master of Air Defense |
| MAD | Margin for Adverse Deviation (finance; also seen as MFAD) |
| MAD | Market Analysis Dormancy |
| MAD | Major Activity Director |
| MAD | Mission Area Directorate |
| MAD | Mobility and Directories |
| MAD | Military Assistance Division (US European Command EUCOM) |
| MAD | Maintenance Action Directive |
| MAD | MilieuAdviesDienst Regionaal (Dutch: regional environment advice service) |
| MAD | Major Account Designation |
| MAD | Maximum Applicable Dose |
| MAD | Management Accounting Division |
| MAD | Magnetic Anomaly Detector/Detection |
| MAD | Media Advertising and Design (various locations) |
| MAD | Mastertronic Added Dimension (game publisher) |
| MAD | Member Appreciation Day (various organizations) |
| MAD | Multiple Administrative Domain (computing) |
| MAD | Mothers against Decapentaplegic (protein) |
| MaD | Mommy and Daddy (scientists; University of California, San Francisco) |
| MAD | Mayhem and Destruction (gaming clan) |
| MaD | Manufacturing and Design (various locations) |
| MAD | Mesophilic Anaerobic Digestion |
| MAD | Music Art Dance (various organizations) |