| Acronym | Definition |
|---|
| MHC | Mount Holyoke College (South Hadley, MA) |
| MHC | Major Histocompatibility Complex |
| MHC | Mars Hill College |
| MHC | Myosin Heavy Chain |
| MHC | Mutual Holding Company |
| MHC | Mental Health Center |
| MHC | Mental Health Counseling |
| MHC | Mental Health Commission |
| MHC | Mile High Club |
| MHC | Migrant Health Centers (US HRSA) |
| MHC | Michigan Humanities Council |
| MHC | Mental Health Coalition |
| MHC | Mobile Health Clinics |
| MHC | Minehunter, Coastal |
| MHC | Missouri Humanities Council |
| MHC | Manitoba Horse Council (Winnipeg, MB, Canada) |
| MHC | Mount Hope Church (Grand Blanc, MI) |
| MHC | Material-Handling Car |
| MHC | Maryland Horse Council |
| MHC | Millenial Housing Commission |
| MHC | Minor Histocompatibility Complex (immunology) |
| MHC | Mechanical Hydraulic Control |
| MHC | Methodist Health Care |
| MHC | Manufactured Housing Consultant (Canadian Manufactured Housing Institute) |
| MHC | Modern Housing Complex (India) |
| MHC | Mary Holmes College (West Point, Mississippi) |
| MHC | Manufactured Housing Commission |
| MHC | Masonic Healthcare Center (Wallingford, CT) |
| MHC | Mild Hydrocracking Unit |
| MHC | Material Handling Cost (cellular manufacturing systems) |
| MHC | Michigan Historical Commission |
| MHC | Military High Command |
| MHC | management headquarters ceiling (US DoD) |
| MHC | Materiel Handling Crane |
| MHC | Munshi Head Constable (India) |
| MHC | Moto-Club des Hauts Cantons (French: Senior Townships Motorcycle Club) |
| MHC | Multi Hypothesis Correlation |
| MHC | Maritime Historical Conference |
| MHC | Mixed Hepatocellular Carcinoma |
| MHC | Man in the High Castle (Philip K. Dick book) |
| MHC | McGraw-Hill Companies (publishing) |
| MHC | Mental Health Clinic (various organizations) |
| MHC | Medicine Hat College (Alberta, Canada) |
| MHC | Metropolitan Hospital Center (New York, NY) |
| MHC | Mobile Home Community (various locations) |
| MHC | Macaulay Honors College (New York) |
| MHC | Mars Hill Church (Seattle, WA) |
| MHC | Mini HiFi Component |