| Acronym | Definition |
|---|
| ME | Middle English |
| ME | Middle East |
| ME | Maine (US postal abbreviation) |
| ME | Millennium Edition (Microsoft Windows) |
| ME | Medical Examiner |
| ME | Modern English |
| ME | Middle Earth |
| ME | Mode Entry |
| ME | Mobile Electronics |
| ME | Mass Effect (game) |
| ME | Managing Editor (newspaper industry) |
| ME | Mirror's Edge (game) |
| ME | Main Engine |
| ME | Mail Early (slogan of post office) |
| ME | Mechanical Engineer |
| ME | Model Engineer |
| ME | Mobile Equipment |
| ME | Mechanical Engineering |
| ME | Master of Engineering (degree program) |
| ME | Manufacturing Engineering |
| ME | Mid-Engine |
| ME | Marriage Encounter |
| ME | Maximum Effort |
| ME | Maintenance Equipment |
| ME | Spanish North Africa |
| ME | Marine Engineer |
| ME | Mechanical Equipment |
| ME | Mount Everest |
| ME | Moral Education (school subject) |
| ME | Middle East Airlines (Air Liban, Lebanon, IATA airline code) |
| ME | Mission Employment (active phase of a mission or exercise) |
| ME | Members Equity (Australian Bank) |
| ME | Mutant Enemy |
| ME | Motion Estimation (part of temporal redundancy coding technique used in digital television) |
| Me | Maître (French title) |
| ME | Messerschmitt (German aircraft manufacturer) |
| ME | Melissa Etheridge (musician) |
| ME | Miscellaneous Equipment |
| ME | Ministry of Environment |
| ME | Medway (postcode, United Kingdom) |
| ME | Opening Information (filename extension; as in READ.ME) |
| ME | Master Electrician |
| ME | Mobility Equipment |
| ME | Macro Economics |
| ME | Mechanized (welding) |
| ME | Mission Essential |
| ME | Multi-Edit |
| ME | Microwave Engineering |
| ME | Ministério da Educação (Portuguese Ministry for Education) |
| ME | Minimum Energy |
| ME | Maximum Entropy |
| ME | Materials Engineer |
| Me | Methyl Group (-ch3) |
| ME | Month Ending |
| ME | Myalgic Encephalomyelitis |
| ME | Muzzle Energy |
| ME | Molecular Electronics |
| ME | Main Effort |
| ME | Micro-Economics |
| ME | Moneda Extranjera (Spanish: Foreign Currency) |
| ME | Metabolizable Energy |
| ME | Master's Degree in Engineering |
| ME | Multiengine |
| ME | Mission Économique (French: Economic Mission; various locations) |
| ME | Mental Endurance (Rifts RPG) |
| ME | Medicina Estetica |
| ME | Management Entity |
| ME | Mobiele Eenheid |
| ME | Montreal Exchange |
| ME | Marine Enlisted |
| ME | Messina, Sicilia (Italian province) |
| ME | Managed Entity |
| ME | Minimum Evolution |
| ME | Maintenance Entity (ITU-T) |
| ME | Mechanical End |
| ME | Mission Evangélique (French) |
| ME | Maneuver Enhancement (Brigade) |
| ME | Ministria e Ekonomisë (Ministry of Economics, Albania) |
| ME | Moniteur-Educateur (French: Teacher for Children with Difficulties) |
| ME | Mental Excellence (education) |
| ME | Margin Enhancement |
| ME | Mature Equivalent |
| ME | Mass Excavation (hydraulic excavators) |
| ME | Molecular Emission |
| ME | Managed Element |
| ME | Moessbauer Effect |
| ME | Mapping Entity |
| ME | Muse Elf (gaming) |
| ME | Multiple Exceptionalities (education) |
| ME | Manpower Estimate |
| ME | Minimum Number of Errors |
| ME | Main Etch (semiconductor gate etching) |
| ME | Mirador Electoral (Guatemala) |
| ME | Marine Etablissement (Dutch) |
| ME | Microcode Engineer |
| ME | Military Special Delivery (Scott Catalogue prefix; philately) |
| ME | Missile Enable |
| ME | Music Exhibitioner |
| ME | Morristown and Erie Railway Incorporated |
| ME | Multi Equipos (Guatemala) |
| ME | Motion Executor |
| ME | Maintenance/Methods Engineering |