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Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 hap-lotypes on cyclosporin disposition in heart transplant recipients.
The following key words were used: "ABCB1 or MDR1 or P-glycoprotein", "polymorphism", "colorectal" and "cancer or neoplasm or tumor".
There was no difference in distribution of MTHFR 1298C, MDR1 1236T and MDR1 3435T variant allele frequencies between Indian and European healthy subjects.
Genotipos para el gen MDR1 en distintas razas de perros en Australia.
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
It has been shown to increase cytochrome P450 (CYP450) (Braun 2005), in particular CYP3A4 (Durr 2000), as well as increasing Pglycoprotein/ MDR1 expression with a 3.
Its glucoside derivative dioscin reverses adriamycin-induced Multidrug-Resistant (MDR) through down-regulating MDR1 expression via NF-kB signaling pathway inhibition in K562 cells (Wang et al.
CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients.
The CYP3A gene cluster is located at chromosome 7, just 119 kb away from the ABCB1 locus, which codes MDR1 (P-glycoprotein), the best-characterized phase III drug transporter and one of the major determinants of the absorption, distribution, metabolism, and excretion/toxico-logic profiles for a large range of hydrophobic exogenous substrates, including nearly every category of clinically important drugs, with a substrate spectrum similar to that of CYP3A enzymes.
RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells.
Publication on ERCC1 and MDR1 Expression in Bladder Cancer - Data from Company sponsored gene expression analysis published in Neoplasia associated high expression of multidrug resistance gene 1 (MDR1) and excision repair cross-complementing 1 (ERCC1) gene expression with inferior outcome after adjuvant chemotherapy in patients with locally advanced bladder cancer.
Chromatin immunoprecipitation (ChIP) assay indicated that sinapine inhibited binding of the transcription factor NF-[kappa]B to the MDR1 promoter.
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- MDR system
- MDR tuberculosis
- mdr-1 gene