MeCP2


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AcronymDefinition
MeCP2Methyl CpG (Cytosine Phosphate Guanine) Binding Protein 2
References in periodicals archive ?
Like many other people, we expected that giving MECP2 to mice that were already sick would not work," said Bird.
When MeCP2 grabs onto DNA, it can limit the activity of genes to which it attaches.
Michele did not know she carried a genetic disorder MECP2 duplication syndrome.
About the Rett Syndrome Research Trust - The Rett Syndrome Research Trust is a non-profit exclusively devoted to global research on Rett Syndrome and related MECP2 disorders.
We measured mRNA levels Svs4, Ltf, Pgr (progesterone receptor), Stat3, Stat5a, DNMT1, DNMT3A, DNMT3B, MeCP2, MBD2, MBD3, HDAC1, and HDAC2 using SYBR green assays (Applied Biosystems, Foster City, CA).
Mandel said that gene therapy is well suited for this disorder, as MECP2 binds to DNA throughout the genome, there is no single gene currently that we can point to and target with a drug.
Blake McMillan was diagnosed with MeCP2 duplication syndrome three weeks after his birth on March 21 last year.
Ms Bloom said testing on mice at the University of Edinburgh in 2007 proved the condition can be reversed by restoring levels of the protein Mecp2.
Thus, in an examination of Rett Syndrome research in humans and mice, the symbols MeCP2, MeCP2, Mecp2, and Mecp2 are used prolifically.
Mutations in the MeCP2 gene and, consequently, the resulting protein that alter transcription of the gene encoding BDNF and affect synaptic plasticity are thought to underlie a neurodevelopmental disorder, Rett syndrome (Chahrour and Zoghbi 2007; Chang et al.
Gross rearrangements of the MECP2 gene are found in both classical and atypical Rett syndrome patients.
We use examples of assays that were developed for the MECP2 and the SMAD4 genes to demonstrate specific challenges associated with the validation of DNA sequencing assays.