| Acronym | Definition |
|---|
| MDE | Maryland Department of the Environment |
| MDE | Michigan Department of Education |
| MDE | Mississippi Department of Education |
| MDE | Model-Driven Engineering |
| MDE | Minnesota Department of Education |
| MDE | Major Depressive Episode |
| MDE | Master of Distance Education |
| MDE | Minnesota Democrats Exposed (political website) |
| MDE | 3,4-Methylenedioxy-N-Ethylamphetamine (empathogenic/psychedelic drug closely related to MDMA) |
| MDE | Microsoft Data Engine |
| MDE | Mobile Daten-Erfassung (German) |
| MDE | Major Defense Equipment |
| MDE | Mechanical Design Engineer |
| MDE | Market Development Engineering |
| MDE | Mobile Data Entry |
| MDE | Multiple Data Entry |
| MDE | Microsoft Development Environment |
| MDE | Managed Desktop Environment (HP) |
| MDe | Ministerio de Defensa de España (Ministry of Defense) |
| MDE | Minimum Distance Estimator |
| MDE | Medellin, Colombia - La Playas (Airport Code) |
| MDE | Main Diesel Engine (naval engineering) |
| MDE | Aeropuerto Olaya Herrera (Medellin) |
| MDE | Manufacturing Development Engineering |
| MDE | Motor Drive Electronics |
| MDE | M Data Extractor (middleware) |
| MDE | Mucinous Ductal Ectasia |
| MDE | Mechanism Drive Electronics |
| MDE | Missile Defense Element (Army) |
| MDE | Main Propulsion Diesel Engine |
| MDE | Mechanical Drive Electronics |
| MDE | Modified Dirac Equation |
| MDE | Molecular Design of Explosives |
| MDE | MacBean Design-East (design consultancy) |
| MDE | Motor Drive End (electric motors) |