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| Acronym | Definition |
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| MLE | Maximum Likelihood Estimation | | MLE | Maximum Likelihood Estimate | | MLE | Managed Learning Environment | | MLE | Mid-Level Exception (athletic contacts) | | MLE | Magazine Lee Enfield (firearms) | | MLE | Medical Laboratory Evaluation (Medical Laboratory Proficiency Testing Program, Washington, DC) | | Mle | Mycobacterium Leprae | | MLE | Multi-Lamellar Emulsion | | MLE | Mesoscale Lightning Experiment | | MLE | Modified Ludzack-Ettinger (process used for wastewater treatment) | | MLE | MAGTF (Marine Air-Ground Task Force) Liaison Element | | MLE | Male, Maldives - Male International (Airport Code) | | MLE | Magical Law Enforcement (Harry Potter) | | MLE | Midline Episiotomy (obstetrics) | | MLE | Major League Equivalency (baseball statistic) | | MLE | Molecular Layer Epitaxy | | MLE | Multi-Level Effects | | MLE | Marine Liaison Element | | MLE | Mode of the Likelihood | | MLE | Multiple Lines of Evidence | | MLE | Missile Launch Envelope | | MLE | Model Law Engineer (National Council of Examiners certification for Engineering and Surveying) | | MLE | Microprocessor Language Editor | | MLE | Multi-Line Entry | | MLE | Mission Level Evaluation | | MLE | Militaire Luchtvaart Eis | | MLE | Mid-Latitude Ecosystem | | MLE | Maximum Loss Expectancy (insurance) | | MLE | Ministry of Labour and Environment (Bangladesh) | | MLE | Medium to Large Enterprise |
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