The study results published in Nature Biotechnology describe the development and test validation of microRNA
expression profiles for identification of tumor origin.
Levin, a recognized leader in both drug development and microRNA
therapeutics, comes at an important time in miRagen's business evolution," said William S.
In case the microRNA
is found to be correlative to the disease, Rosetta may further advance the microRNA
into a diagnostic for patient identification and stratification.
The findings suggest a new strategy for treating cancer and diseases of the immune system, the researchers say, and a new role for microRNA
in the body.
But it was still possible that p53 mutations might disrupt the machinery that chops RNA into microRNA
, says Kohei Miyazono of the University of Tokyo.
Combining Rosetta Genomics know-how and proprietary technologies with Columbia University Medical Center's expertise in cancer, researchers will screen for microRNAs
that may be used as potential biomarkers and drug targets for these NHL indications.
MiRagen combines world recognized leadership in cardiovascular medicine with unprecedented in-house expertise in microRNA
biology and chemistry.
M2 PHARMA-January 15, 2014-Regulus sets up R&D division for microRNAs
The study shows that a microRNA
-302 mimic, delivered by a specially constructed lentivirus, was sufficient to enable neural differentiation of mouse embryonic stem cells that lacked Dgcr8, a vital gene for the processing of the more than 2,000 microRNAs
Most studies that have evaluated microRNA
expression have performed serum or tissue quantification (FUJIWARA-IGARASHI et al.
In conjunction, the company's application '879 claims hsa-miR-551b-3p, its complement and a sequence of at least 18 nucleotides identical to it, as well as a probe and a vector comprising this microRNA
The discovery of microRNA
is extremely new to the biology world; its discovery is credited to Victor Ambros and his research team in 1993.