| Acronym | Definition |
|---|
| MSSC | Mississippi Supreme Court |
| MSSC | Manufacturing Skill Standards Council |
| MSSC | Mississippi Safe Schools Coalition |
| MSSC | Multiple Sclerosis Society of Canada |
| MSSc | Master of Social Science |
| MSSC | Marine Society and Sea Cadets (UK) |
| MSSC | Medium SEAL Support Craft |
| MSSC | Most Severe Single Contingency (energy management) |
| MSSC | Midland Speed Skating Club (Midland, Michigan) |
| MSSC | Missouri Seismic Safety Commission |
| MSSC | Muscle Shoals Sailing Club (Alabama) |
| MSSC | Multicultural Student Services Center |
| MSSC | Maui Space Surveillance Complex |
| MSSC | Microscopic Society of Southern California |
| MSSC | Mobile Services Switching Center |
| MSSC | Maritime Satellite Switching Center (ITU-T) |
| MSSC | Mobile Satellite Switching Center |
| MSSC | Mass Storage System Communicator |
| MSSC | Mount Shasta Soaring Center |
| MSSC | Mount Shasta Soaring Center (California, aviation) |
| MSSC | Medium-Speed, Single Copy (printer) |
| MSSC | Multi-Band Switch and Service Configuration |
| MSSC | Missionaries of the Sacred Hearts of Jesus and Mary (religious order) |
| MSSC | Magnavox Signaal Systems Company |
| MSSC | Middle School Student Council (various locations) |
| MSSC | Managed Services Support Center |
| MSSC | Mean Summer SCRIM (Sideways Co-Efficient Routine Investigation Machine) Coefficient (engineering) |
| MSSC | Maridos Sometidos Social Club (Spanish: Submitted Husbands Social Club; Fredericksburg, VA) |