| Acronym | Definition |
|---|
| MSD | Most Significant Digit |
| MSD | Metropolitan Sewer District |
| MSD | Msida (postal locality, Malta) |
| MSD | Musculoskeletal Disorder |
| MSD | Marine Sanitation Device |
| MSD | Mass Storage Device |
| MSD | Maryland School for the Deaf |
| MSD | Master SCUBA Diver |
| MSD | Mass Selective Detector |
| MSD | Microsoft Diagnostics (msd.exe) |
| MSD | Mahendra Singh Dhoni (Indian cricket player) |
| MSD | Materials Science Division |
| MSD | Mean Square Displacement (physics) |
| MSD | Missouri School for the Deaf |
| MSD | Macromolecular Structure Database |
| MSD | Medical Stores Department |
| MSD | Marine Safety Detachment |
| MSD | Moisture Sensitive Device (electronic assemblies) |
| MSD | Mobiler Sozialer Dienst |
| MSD | Mississippi School for the Deaf |
| MSD | Maintenance Support Device |
| MSD | Municipal Setting Designation (Texas Commission on Environmental Quality) |
| MSD | Master of Science in Dentistry |
| MSD | Multiple Site Damage |
| MSD | Minimum Safe Distance |
| MSD | Male Sexual Dysfunction |
| MSD | Minimum Significant Difference |
| MSD | Mean Sac Diameter (gestational sac measurement) |
| MSD | Manufacturing System Design |
| MSD | Multi-Spark Discharge (engine ignition) |
| MSD | Management Support Division |
| MSD | Management Systems Designers, Inc |
| MSD | Missile Systems Division |
| MSD | Media System Design (academic program) |
| MSD | Mobile Security Division |
| MSD | Master Slave Determination |
| MSD | Modem Sharing Device |
| MSD | Montana School for the Deaf |
| MSD | Motor and Social Development |
| MSD | Management Systems Division |
| MSD | Material Support Division |
| MSD | Material Support Date |
| MSD | Mission Support Division |
| MSD | Marble Spleen Disease |
| MSD | Moderate to Severe Disabilities |
| MSD | Mission-Specific Data (National Geospatial-Intelligence Agency) |
| MSD | Movement pour le Socialisme et la Democratie (Comoros) |
| MSD | Microgravity Science Division (NASA) |
| MSD | Multiple Symbol Detection |
| MSD | Museum of Scientific Discovery |
| MSD | Makai Senki Disgaea (Japanese PS2 game) |
| MSD | Minesweeping, Drone |
| MSD | Merck, Sharp & Dohm |
| MSD | Motor Speech Disorder |
| MSD | MNSTC-I Support Division (US DoD) |
| MSD | Millard School District (Delta, UT, USA) |
| MSD | Molten Salt Destruction |
| MSD | Mobile Storage Device |
| MSD | Manufacturing, Supply and Distribution |
| MSD | Multi-Stage Detector |
| MSD | Minimum Symbol Distance |
| MSD | Marginal Support Date |
| MSD | Munitions Systems Division |
| MSD | Magnetic Signature Duplicator |
| MSD | Mapping Support Data |
| MSD | Material Support Data |
| MSD | Multi Satellite Dispenser |
| MSD | Major System Demonstration |
| MSD | Medium Screen Display |
| MSD | Material Selection Diagram |
| MSD | Manufacturer Ship Direct |
| MSD | Maintenance Support Date |
| MSD | Marinestoomvaartdienst (Dutch) |
| MSD | Microsoft Solutions Directory |
| MSD | Mine Safety Distance |
| MSD | Manual Simulations Division |
| MSD | Multiskeletal Disorder |
| MSD | Mortar Simulation Device |
| MSD | Mobilization Support Detachment |
| MSD | Memorial Service Detachment (funeral military service) |
| MSD | Metal Shipment Documentation |
| MSD | Marketing Services Description |
| MSD | Microwave Spray Drying |
| MSD | MustSeeDaily (website) |
| MSD | Multichannel System Designator |
| MSD | Multi-Set Decipherable |
| MSD | Microwave Semiconductor Device |
| MSD | Multi-Sensor Detection |
| MSD | Modular Security Device |
| MSD | Minimum Squared Distance |
| MSD | Morning Star Development |
| MSD | Mission System Development |
| MSD | Marsh Sound Design (Corte Madera, CA) |
| MSD | Managed Services Division |
| MSD | Mukilteo School District (Washington) |
| MSD | Mean Shortest Distance (statistics) |
| MSD | Municipal School District |
| MSD | Maximum Standard Deviation (statistics) |
| MSD | McComb School District (Mississippi) |
| MSD | Municipal Service District (various locations) |