| Acronym | Definition |
|---|
| MPE | Max-Planck-Institut für Extraterrestrische Physik |
| MPE | Maximum Permissible Exposure |
| MPE | Multi Protocol Encapsulation |
| MPE | Modern Process Equipment |
| MPE | Molecular Phylogenetics and Evolution (journal) |
| MPE | Most Probable Explanation |
| MPE | Mors Principium Est (band) |
| MPE | Multi-Programming Executive (HP Operating System) |
| MPE | Multi-Photon Excitation |
| MPE | Mercury Playback Engine (Adobe Systems Incorporated) |
| MPE | Multiphase Extraction |
| MPE | Moving Pictures Expert Group (filename extension synonymous with MPG and MPEG) |
| MPE | Mechanical and Production Engineering |
| MPE | Mission to Planet Earth |
| MPE | Minimum Phone Error |
| MPE | Mean Percent Error |
| MPE | Master of Physical Education |
| MPE | Medical Physics Expert (EU) |
| MPE | Multiservice Provider Edge (Nortel) |
| MPE | My Point Exactly |
| MPE | Multiprofessional Education |
| MPE | Multi-sensor Precipitation Estimator (US National Weather Service) |
| MPE | Minimum Probability-of-Error |
| MPE | Master of Psychiatric Epidemiology |
| MPE | Message Passing Environment |
| MPE | Magnetic Particle Examination |
| MPE | Maximum Permissive Exposure |
| MPE | Maggi, Pierce & E.J. (band) |
| MPE | Mission Planning Environment |
| MPE | Miniature PLGR (Precision Lightweight GPS Receiver) Engine |
| MPE | Midwest Products and Engineering |
| MPE | Mostardi Platt Environmental (est. 1976) |
| MPE | Maximum Predicted Environment |
| MPE | Map Publishing Environment |
| MPE | Master of Public Education |
| MPE | Metamath Proof Explorer |
| MPE | Maximum Potential Energy |
| MPE | Maximum Power Exposure |
| MPE | Manual Plot Entry |
| MPE | Medical Practice Executive |
| MPE | Manchester Phase Encoding (clock signal) |
| MPE | Morello Park Elementary (Martinez, CA) |
| MPE | Maryland Photogrammetric Engineering, Inc (Silver Spring, MD) |
| MPE | Mission Processing Equipment |
| MPE | Mission and Performance Envelopes |
| MPE | More Powerful Explosive |
| MPE | Markov Pefect Equilibria |
| MPE | Missing Planning Element |
| MPE | Malignant Pleural Effusion |
| MPE | Manufacturing Process Engineer |
| MPE | Ministry of Petroleum and Energy (Norway) |
| MPE | Market Participant Exception (constitutional law) |
| MPE | Mail Processing Equipment (USPS) |
| MPE | Major Program Element |
| MPE | Microsoft Photo Editor (software) |
| MPE | Mcafee Policy Enforcer (software) |
| MPE | Mustang Performance Equipment (Racing; Whitman, MA) |