| Acronym | Definition |
|---|
| MPO | Metropolitan Planning Organization |
| MPO | Myeloperoxidase |
| MPO | Metal Gear Solid (video game) |
| MPO | Malaysian Philharmonic Orchestra |
| MPO | Mercury Planetary Orbiter |
| MPO | Memory Placement Optimization (Sun Microsystems) |
| MPO | Military Post Office |
| MPO | Maintenance of Public Order |
| MPO | Master Police Officer |
| MPO | Mobile Phone Organizer |
| MPO | My Personal Opinion |
| MPO | Ministerstvo Prumyslu A Obchodu (Ministry of Industry and Trade; Czech Republic) |
| MPO | Multi-Fiber Push On (connector) |
| MPO | Music Power Output |
| MPO | Manufacturing Process Optimization |
| MPO | Mobile Post Office |
| MPO | Mission Payload Operator |
| MPO | Manila Philharmonic Orchestra (Philippines) |
| MPO | Manual Pitch Override |
| MPO | Military Protection Order (restraining order) |
| MPO | Minnesota Philharmonic Orchestra (Minneapolis , MN) |
| MPO | Multipath Optical (fiber optic communications) |
| MPO | Military Pay Order |
| MPO | Mt. Pocono, Pennsylvania (Airport Code) |
| MPO | Main Phase Onset |
| MPO | Manufacturing Production Order |
| MPO | Master of the Psychology of Organization |
| MPO | Measurable Performance Object |
| MPO | Major Project Office |
| MPO | Metadata Protocol Officer |
| MPO | Minefield Performance Objective |
| MPO | Mission Planning Office (NASA) |
| MPO | Market Place Operator |
| MPO | Michael Peters Organisation (fansite) |
| MPO | Mail Processing Operation (USPS) |
| MPO | Medical Product Outsourcing (trade magazine) |
| MPO | Master Purchase Order (sales record) |
| MPO | Multiple Payment Option (gifts) |