Concordant with the process of EMT, vimentin was expressed in 100% of cases (Figure 4, D) and N-cadherin
in 46% of cases, whereas E-cadherin was lost in the majority of cases (15%; Figure 4, E).
Mouse monoclonal antibodies (mAb) against E-cadherin (610181), N-cadherin
(610920) and Fibronectin (610077) were from BD Pharmingen, San Diego, CA, USA.
Expression of P-cadherin, but not E-cadherin or N-cadherin
, relates to pathological and functional differentiation of breast carcinomas.
By interacting with SIRT7, Zeb1, and the Twist-MBD1 complex, SIRT1 represses the transcription of epithelial genes including E-cadherin, while increasing the expression of mesenchymal genes such as N-cadherin
A switch from E-cadherin to N-cadherin
expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer.
To study the role of Sertoli-germ cell interactions in DBP-induced germ cell aggregation, we examined expression of cell-cell adhesion molecules, APC, espin, vimentin, and N-cadherin
(Bartles et al.
The EMT is usually accompanied by E-cadherin loss and N-cadherin
Scientists in Bristol have now produced a smaller, soluble form of N-cadherin
that has the ability to stabilise plaques.
Expression of NCAM-180 and N-cadherin
during development in two south-american anuran species (Bufo arenarum and Hyla nana).
Expression of ECM proteins and N-cadherin
results in the reorganization of the outer cells of each somite into an epithelium (an MET; Linask et al.
ADH-1, our lead biotechnology compound, selectively targets N-cadherin
, a protein present on certain tumor cells and established blood vessels that feed solid tumors.
ADH-1 is a biotechnology compound which selectively targets N-cadherin
, a protein present on certain tumor cells and the blood vessels of solid tumors.