A specialist in neuroimmune dysfunction, who is combining NAD+ with photoactivated light therapy, Dr.
And one of the founding pioneers in intravenous NAD+ therapy, Dr.
Researchers believe the medical implications for humans indicate that supplementation with nicotinamide riboside at doses of 100-250 mg or more can increase NAD+ levels systemically.
Editor's Note: The study's authors note that the exact mechanism of declining NAD+ levels and their basic importance to the aging process are still under investigation.
As organisms age, NAD+
levels drop that leads to a decrease in mitochondrial health and age-related health issues.
The compound, called nicotinamide riboside (NR) - a natural NAD+ precursor found in foods like milk - as well as other NR derivatives have already been proven to protect against cell death and axonal degeneration in cultured cells and in models of spinal cord injury.
NAD+ is known to play a key role in human cells by activating proteins called sirtuins that help the cells survive under stress.
In 2004, Charles Brenner, PhD, discovered that nicotinamide riboside occurs in milk and that it can convert to NAD+ in humans.
The trial revealed the superiority of nicotinamide ribosome in boosting NAD+ and the activity of sirtuin enzymes.
The researchers point out that NAD+
synthetase is responsible for making NAD+
, a coenzyme found in all living cells that is involved in regulating many cellular processes and in reduction-oxidation metabolic reactions.
Published research confirms that NAD+
levels decline as we age (7,8) and represent a fundamental, systemic contributor of aging.
levels decline, mitochondrial function is impaired, resulting in fewer mitochondria surviving.