3] Nonstandard abbreviations: HER2, human growth factor receptor 2; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization; FDA, US Food and Drug Administration; NCCTG
, North Central Cancer Treatment Group; NSABP, National Surgical Adjuvant Breast and Bowel Project; CEP17, chromosome 17 centromere enumerating probe.
was founded in 1977 on the premise that the community practice setting, where most cancer care occurs, is the most appropriate venue for conducting clinical trials.
In the NCCTG
trial, the delay between the completion of AC chemotherapy appeared to reduce the frequency of cardiac dysfunction.
The tumor samples examined in the study came from NCCTG
N9831, a phase III randomized, multicenter clinical trial that tested adjuvant Herceptin given with, or following, chemotherapy with paclitaxel, compared with chemotherapy alone.
Furthermore, in the adjuvant setting, frequency of CNS metastasis as the first site of relapse was numerically greater in the trastuzumab arms in the HERA, NSABP B-31 and NCCTG
N9831 trials [32,33].
N9831 (US), NSABP B-31 (US), HERA - HERceptin Adjuvant (international), BCIRG 006 (international)
study enrolled its first patient in June 2000 and has enrolled 3,406 patients; the NSABP study began enrolment in March 2000 and has enrolled 2,085 patients.
Tumor SPARC microenvironment signature (SMS) and plasma levels in a phase II trial of unresectable stage IV melanoma treated with nab-paclitaxel and carboplatin: a translational study of NCCTG
trial N057E (Abstract #8578)
As some of the clinical trials on Herceptin (such as NSABP B-31, BCIRG 006, NCCTG
9831) mature, some of these pivotal validation studies can be completed.
study enrolled its first patient in June 2000 and has enrolled 3,406 patients to date; the NSABP study began enrolment in March 2000 and has enrolled 2,085 patients to date.
Focal HER2/neu amplified clones partially account for discordance between immunohistochemistry and fluorescence in situ hybridization results: data from NCCTG
N9831 intergroup adjuvant trial.
N0937: Platinum chemotherapy (Cisplatin) and brostacillin for metastatic triple-negative breast cancer