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Elevations in IL-2, IL-8 and IL-10 were significantly increased in CeD compared to NCGS, with IL-2 being the most sensitive.
During a discussion of the results, attendees questioned whether the study design, particularly the failure to biopsy patients for celiac disease at enrollment and the short 7-day washout period, was sufficient to answer the question of identifying patients with NCGS.
Symptoms of NCGS are variable and overlap with symptoms found in people with celiac disease, wheat allergy, and especially irritable bowel syndrome (IBS), another condition without any biological markers to assist in diagnosis.
Overall, a gluten-free diet is neither helpful, nor healthier, for people without celiac disease or NCGS," says Alissa Lupu, RD, CDN, CNSC, a dietitian with the Center for Advanced Digestive Care at New York-Presbyterian Hospital.
Previous studies have demonstrated that 'a substantial number of patients (about 40%) with NCGS will demonstrate a Marsh 1 level of inflammation'.
Since NCGS was formed in 1960, more than 25,000 grid monuments have been established in North Carolina.
Data from the second poster presentation, "Increase in plasma interleukin -2, IL-8, and IL-10 from 2 to 6 hours on oral gluten challenge differentiates between celiac disease and non-celiac gluten sensitivity in patients on gluten-free diet," found that patients diagnosed with celiac disease had highly significant elevations in plasma IL-2 and IL-8 after consuming a standardized gluten food challenge, while those with NCGS did not.
NCGS, a much less severe reaction to gluten, is estimated to affect as much as six percent of the population--still a minority, but six times more common than celiac disease.
A report conducted in 2009 by the University of California in Los Angeles and commissioned by NCGS found that young women who attended all-girls schools scored higher on their SATs, were more interested in graduate school, and were more interested in typically male-dominated fields such as engineering and mathematics.
20) NCGS is not typically associated with intestinal damage and permeability, in contrast to the overt enterocyte destruction that occurs in celiac disease.