NCMIRNational Center for Microscopy and Imaging Research
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Using a variety of leading-edge imaging technologies, including a new fluorescent tagging technique developed for electron microscopy by UC San Diego Nobel laureate Roger Tsien's lab and colleagues at NCMIR, the scientists created three-dimensional maps of alpha-synuclein distribution both in cultured neurons and in the neurons of mice engineered to over-express the human protein.
The terminals were enlarged, filled with structures we normally don't see," said Daniela Boassa, PhD, a research scientist at NCMIR and the study's first author.