Despite the study reporting higher levels of AGA and IgG anti-betalactoglobulin antibodies in patients with NCWS and multiple food hypersensitivity, the authors suggest the elimination of foods based on IgG food antigen assays should be discouraged in line with a number of international allergy and immunological guidelines.
In concluding the review, the authors describe NCWS as a heterogenous condition includes different subgroups of patients.
This review provides a good overview of NCWS as a potential non-IgE-mediated allergic condition, and highlights the relevance of clinical and laboratory investigations in diagnosis as well as providing discussion around non-immune mediated pathogenic mechanisms.
Carroccio and his colleagues reviewed data on 276 patients diagnosed with NCWS using a double-blind placebo-controlled wheat challenge.
We compared patients suffering from NCSW and irritable bowel syndrome (IBS) to controls with IBS not due to NCWS.
Future studies in NCWS patients should consider the role of diet in the microbiota and, in turn, on the intestinal immune system," Dr.