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Neddylation is a reversible post-translational protein modification whereby a small ubiquitin like protein (UBL), NEDD8 (neural precursor cell expressed developmentally downregulated protein (8), is attached to substrate proteins through a series of enzymatic reactions.
NEDD8 was originally identified as a highly expressed molecule in the embryonic brain.
In the present study, we examined the localization of DCUN1D2 and NEDD8 in the sciatic nerves, and found that these neddylation-related molecules were present mainly in the myelin paranodal regions and Schwann cell bodies.
DCUN1D2 and NEDD8 are enriched in the PNS paranodal region.
20) Therefore, the localization of NEDD8 in the myelinated fibers was examined by double immunostaining using specific antibodies against NEDD8 and MAG.
MEKK1, mitogen-activated protein kinase kinase kinase 1; PKC, protein kinase C; NIK, NF-[kappa]B inducing kinase; NEDD8, neural precursor cell expressed developmentally downregulated 8.
Total Tag SNPs Gene inclusion tag passing Gene SNPs inclusion criteria criteria AHRR 27 24 AIP/ARA9/XAP2 2 0 ARNT 5 4 Canonical AhR AhR 11 8 HSP90 6 4 p23/TGES3 4 4 ARNTL 19 14 CCNT1 3 3 DAP3 3 1 ESR1/ER-a 49 33 GTF2F1 3 1 GTF2F2 9 6 HIF1A/MOP1 6 2 NCOA1/SRC1/RIP160 11 6 NCOA2/SRC2 19 14 NEDD8 4 4 NR2F1 2 2 AhR interacting genes (Entrez Gene) NRIP1/RIP140 10 8 RB1 4 4 RELA/NFKB3 4 2 SMARCA4 10 6 SP1 4 4 SRC 14 10 TAF4 6 4 TAF6 6 4 TBP 6 3 XPO1 5 5 AR 2 0 CREB1 4 3 ERB/ESR2 16 12 GR/NR3C1 18 15 GSTCD 5 5 AhR interacting genes (STRING) GSTM1 1 0 MYC 6 5 PPARA 16 11 RELB 6 4 UGT1A5 16 10 CYP1A1 2 1 CYP1A2 2 1 Dioxin-induced genes CYP1B1 6 5 TP53 5 1 ARNT2 58 36 Genes associated with reproductive CYP17A1 6 4 outcomes: Sone and Yonemoto 2008 9q31.
Independent of NEDD8 cleavage, CSN forms protective complexes with CRLs, which prevents destructive auto-ubiquitination.
Preclinical data published as the cover story in Molecular Cell in January 2010 revealed that NAE uses MLN4924 to create its own inhibitor by forming an adduct, or new molecule, by combining MLN4924 and an NAE substrate called NEDD8.
This adduct blocks the enzyme activity and thereby inhibits the NEDD8 pathway.
For the first time we have a compound that selectively inhibits the activation of the NEDD8 pathway," said James Brownell, Ph.
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- Nedbailo, Anatolii
- Nedbailo, Anatolii Konstantinovich
- Nedbank Group Insurance Brokers
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-activating enzyme E1C
- Nedd8-activating enzyme hUba3
- NEDD8-specific protease
- NEDD9 interacting protein with calponin homology and LIM domains
- NEDD9-interacting protein with calponin homology and LIM domains
- Nedelin, Mitrofan
- Nedelin, Mitrofan Ivanovich
- Nedelkovski, Kole