reported that in kidney transplant recipients on cyclosporine, the inhibition of NFAT
gene expression ranged from nearly complete to approximately 50%, whereas in patients on TAC the [I.
In experiments on mice, the researchers found a number of links between NFAT
and acute pancreatitis.
Cr(VI) treatment did not result in observable NFAT
activation (Figure 2A), whereas UVB exposure, the positive control, resulted in significant NFAT
activation (Figure 2B) in the same stable NFAT
-Luc reporter transfectant.
(Nuclear factor of activated T-cells) is a general name applied to a
SH3BP2 is an activator of NFAT
activity and osteoclastogenesis.
This allows nuclear translocation of NFAT
and subsequent expression of genes implicated in the activation and recruitment of T cells, resulting in an adaptive immune response.
thus enters the cell nucleus, where it binds to a synthetic control sequence and switches on the target gene the researchers have introduced.
24-27) In addition, a fusion between EWSR1 and a gene from a transcription factor family other than ETS, the NFATC2 gene (encodes for a member of the NFAT
transcription factor family), has been described.
T cells and activation of IL-4 gene promoter containing binding sites for the NFAT
(nuclear factor of activated T cells) transcription factor.
Nuclear factor of activated T cells 1 (NFATc1), a transcription factor belonging to NFAT
family, has been demonstrated to act as a master regulator during the terminal differentiation of multinucleated osteoclasts.
The primarysubstrate of Cn, however, is the transcription factor NFAT
(nuclear factor of activated T cells).
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT
and AP-1 by RAS-dependent mechanisms.