Individual eicosanoids are known to act via discrete Gprotein coupled receptors to signal through diverse intracellular pathways, including those regulated by cAMP, protein kinases C and A, PPAR[lambda], NFkB
, and AP-1.
Curcumin helps to suppress NFkB
activation and, as a result, inflammation and a host of its manifestations.
Proteomic screening of variola virus reveals a unique NFkB
inhibitor that is highly conserved among pathogenic orthopoxviruses.
Moreover, PEG-LPrA2 treatment reduced the levels of several leptin-induced molecules within DMBA-MT: OB-R, IL-1R tl, VEGF/VEGFR2, bcl-2, HIF-la and NFkB
(p50 and p105).
The therapeutic potential and benefit of targeting NFkB
in pancreatic disorders and the possible complications and pitfalls of such an approach have been vividly explored.
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkB
, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line.
Additionally, there is evidence for an inhibitory action of FQ antibiotics on NFkB
, a transcription factor central to pro-inflammatory cytokine release, as well as on Toll-like receptor 4, the downstream element that permits LPS to induce TNF synthesis.
They inhibit bone resorption by inhibiting osteoclast differentiation and activity, and they also display anti IL-1, IL-6, anti-TNF-[alpha], anti NFkB
Under similar expression condition, comparable modulation of NFkB
mediated transcriptional regulation was observed.
Mechanisms of immune evasion by renal cell carcinoma: tumour-induced T-lymphocyte apoptosis and NFkB
Suppression of nitric oxide synthase and the down-regulation of the activation of NFKB
in macrophages by resveratrol.
At present, we are engaged in developing two new medicines: the Hepatocyte Growth Factor (HGF) genetic medicine which improves blood circulation by regenerating blood vessels, and NFkB
decoy which controls various inflammations.