NHE3

AcronymDefinition
NHE3Na/H Exchanger Isoform 3
References in periodicals archive ?
Previous reports have shown in vivo that Cd alters the expression of NHE3 and v-[H.
The same effect of Cd on megalin and ClC5 expression was previously observed for other proteins involved in albumin-receptor--mediated endocytosis, including NHE3 and v-[H.
We used dilutions of 1:2 for CAII, 1:400 for NHE3, 1:50 for CFTR, 1:100 for DRA, 1:200 for ATPase [alpha]1, 1:400 for ER[alpha], and 1:400 for ER[beta].
Semi-quantitative relative PCR analysis for NHE3 : Semi-quantitative relative PCR analysis for NHE3 was used for this study because insufficient 3'-end sequence information was available for NHE3 to use the comparative RT-PCR method.
Tenapanor is a minimally-absorbed small molecule inhibitor of NHE3, a transporter of sodium in the gastrointestinal tract.
We are grateful for the substantial investment that AstraZeneca has made in the NHE3 program, and we have been fortunate to have them as a partner," Mr.
Ardelyx and AstraZeneca have executed a termination agreement under which Ardelyx regained all rights for all NHE3 inhibitors previously licensed to AstraZeneca, including tenapanor.
Tenapanor (also known as RDX5791 and AZD1722) is a minimally-systemic small molecule inhibitor of NHE3, a transporter of sodium in the gastrointestinal tract.
Title: Tenapanor, a Minimally Absorbed Small-Molecule Inhibitor of NHE3, Reduces Absorption of Sodium and Phosphorus in Healthy Japanese Volunteers(abstract # 2498; Poster Board #FR-PO965)
Tenapanor (also known as RDX5791 and AZD1722) is a minimally-absorbed small molecule inhibitor of NHE3, a transporter of sodium in the gastrointestinal tract.
The deal includes Ardelyx's lead candidate, RDX5791, an orally administered NHE3 sodium transport inhibitor.
Phase IIa: -- the NHE3 inhibitor (AVE0657) in sleep apnea; -- the monoclonal antibody (AVE1642) in the treatment of breast cancer; -- ataciguat, a guanylate cyclase activator, in neuropathic pain; -- SAR97276 in the treatment of malaria; -- a therapeutic vaccine against melanoma; -- anti-rabies monoclonals (post-exposure prophylaxis).