Glomerular filtration rate estimated by Cockroft-Gault formula was lower both in NICMP and PAH subgroups as compared to those in controls (p<0.
0001), this correlation was attenuated in PAH and NICMP subgroups (r=0.
35) showed a correlation with serum NGAL in PAH, NICMP and control subgroups.
Despite the mild impaired eGFR, neither serum NGAL, nor urinary NGAL levels were found to be elevated in PAH and NICMP subgroups as compared to those in controls.
In present study, we assessed in serum and urinary NGAL levels in two settings of HF which may be associated with low renal arteriovenous perfusion gradients, in left-sided HF due to NICMP and in right-sided HF secondary to severe PAH.
However, despite the mild impairment in CI and eGFR, increased BNP levels in both subsets of HF, a severe PAH and preserved LV EF % in right-sided HF, and moderate to severe LV dysfunction concomitant with nearly normal PAPs in NICMP might provide an opportunity to investigate the NGAL production in these subsets of HE Furthermore, absence of the direct pressure data derived from the level of renal veins may be considered a limitation for our hypothesis concerning the interactions among venous congestion, renotubular dysfunction and NGAL production.
Despite the impaired eGFR in left-sided HF due to NICMP and right-sided HF due to PAH, neither serum NGAL, nor urinary NBAL levels are elevated in these patients.