Cell repositories like the NIGMS Repository at Coriell have become a key money and time saving resource for scientists.
In addition to funding the six center grants, NIGMS supports individual grants and grant supplements to advance stem cell research.
Supported in part by NIGMS R25 GM50117 and REAP, NAS.
For the simulated testing, pellets from the project cell lines were prepared as above and were accompanied by pellets from 2 additional cell lines that previously had been shown to be negative for all mutations carried by the project cell lines [GM03469 and GM00130; NIGMS Human Genetic Cell Repository; characterization of these cell lines is described in the accompanying Technical Brief (11)].
Each NIGMS center is a collaborative effort involving several researchers who will work together on specific pilot projects.
This publication was made possible by Grant Number P50 AT00155, jointly supported by the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS), the Office for Research on Women's Health (ORWH), and the National Institute of General Medicine (NIGMS), and it's contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCCAM, ODS, ORWH, NIGMS or NIH.
Among the NIGMS Protein Structure Initiative's goals are to develop faster, more streamlined methods for structural determination specifically for crystallography.
NIGMS is part of the National Institutes of Health.
SV40 transformed XPA fibroblast GM04312C cells and human normal fibroblast GM00038B cells were obtained from the NIGMS (National Institute of General Medical Sciences) Human Genetics Cell Repository (Camden, NJ).
Currently, NIGMS research training programs are only open to holders of MD and PhD degrees (35).
We screened 13 cell lines from the NIGMS Repository for medically important mutations in 11 different genes: CFTR, F5, F2, MTHFR, HFE, GJB2 (connexin 26), FMR1 (fragile X), HBA1/HBA2 ([alpha]-thalassemia), FGFR3, HD, and HbS/HbC.
NIGMS will supply $150 million over five years to seven research groups based throughout the US.