NKCC2

AcronymDefinition
NKCC2Sodium-Potassium-Chloride Transporter 2
References in periodicals archive ?
3) The increase in the expression of NKCC2 can occur as a compensatory mechanism.
En un estudio realizado por Starremans y colaboradores (13) se encontraron diferentes mutaciones en el gen NKCC2, a saber:
En la evaluacion funcional del NKCC2 se encuentra que las mutaciones codifican para una proteina estable y bien ubicada pero no funcional, lo que genera una merma en la reabsorcion de sales en el asa ascendente gruesa de Henle y un deterioro en el transporte transepitelial de calcio.
Bartter[acute accent]s syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K2Cl cotransporter NKCC2.
Moreover, the authors demonstrated that protein extracts from the outer membrane of Leptospira santarosai serovar Shermani induced suppression of NKCC2 gene transcription in murine TAL cells [25].
The observation of increased expression of iNOS in tubular cells after exposure to leptospiral proteins in vitro is of relevance since nitric oxide (NO) is an physiological inhibitor of NKCC2, a postulated target of leptospiral toxins [36].